What Is Snap-8? Acetyl Octapeptide-3 Sequence and Properties

Snap-8, registered under the INCI name acetyl octapeptide-3, is a synthetic eight-residue peptide with an acetyl cap at the N-terminus and an amide at the C-terminus. Its sequence is Ac-EEMQRRAD-NH2, its formula C41H65N13O16, its molecular weight about 1075.2 Da and its CAS number 868844-74-0.

How does it relate to Argireline?

Argireline, also called acetyl hexapeptide-3, is a six-residue peptide with the sequence Ac-EEMQRR-NH2. Snap-8 extends that sequence by two additional residues, alanine and aspartate, at the C-terminus. Both were designed to mimic a portion of the SNAP-25 protein, a component of the SNARE complex that mediates vesicle fusion [1].

Where does it appear in the literature?

Snap-8 appears primarily in cosmetic research literature and in topical formulation studies. It is not listed in any pharmacopeia. The published literature consists mainly of in vitro cell work and formulation stability data, not studies in intact organisms.

What should a lab report show?

Identity by mass spectrometry at about 1075 Da, purity by HPLC at 214 nm, and acetyl cap confirmation. The methionine at position 3 is prone to oxidation, producing a peak at plus 16 Da, so oxidation should be assessed.

Frequently asked questions

Is Snap-8 the same as Argireline?

No. Argireline is a hexapeptide (six residues, about 889 Da); Snap-8 is an octapeptide (eight residues, about 1075 Da) with two additional C-terminal residues.

What is the SNARE complex?

SNARE stands for soluble N-ethylmaleimide-sensitive factor attachment protein receptor. It is a group of proteins involved in membrane vesicle fusion, first characterized structurally in the late 1990s [1].

Does FLASK list Snap-8?

Yes, as Snap-8 200 mg, with structure data on the product page.